The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.
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Somatic instability detected in blood DNA shows simple and rare intra-allelic events two to three orders of magnitude lower than in sperm. Close mobile search navigation Article navigation. While other genomes mouse, rat and pig contain minisatellite-like sequences, none was found to be hypermutable.
Citing articles via Web of Science H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing.
Minisatellites have been implicated [ citation needed ] as regulators of gene expression e. Emery’s Elements of Medical Genetics, 12th.
It has been proposed that minisatellite sequences encourage chromosomes to swap DNA. If you originally registered with a username please use that to sign in.
Hypervariable ‘minisatellite’ regions in human DNA – Semantic Scholar
Learn how and when to remove these template messages. Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal’s discretion. In alternative models, it is the presence of neighbouring double-strand hotspots which is the hukan cause of minisatellite repeat copy number variations. WikiProject Genetics may be able to help recruit an expert. They are generally non-coding DNA but sometimes are part of possible genes.
We present DNA sequences flanking cloned hypervariable human minisatellites. From Wikipedia, the free encyclopedia.
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Sign in via your Institution Sign in. Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting the chromosomes from damage.
Finally, with the discovery of tandem iterations of simple sequence motifs, the term microsatellites was coined. Minisatellite variant repeat mapping by PCR MVR-PCR has been extensively used to chart the interspersion patterns of variant repeats along the array, which provides details on the structure of the alleles before and after mutation.
Sequences flanking the repeat arrays of human minlsatellites: Since all hypermutable minisatellites contain internal variantsthey provide extremely informative systems for analyzing the complex turnover processes that occur at this class of tandem repeat.
Views Read Edit View history. A novel human nonviral retroposon derived from an endogenous retrovirus. The human telomere sequence itself is a tandem repeat: For the size class of orbiting spacecraft, see miniaturized satellite.
You must accept the terms and conditions. Abstract We present DNA sequences flanking cloned hypervariable human minisatellites. Minisatellites also constitute the chromosomal telomeres, which protect the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes. Dynamic evolution of megasatellites in yeasts. These findings have suggested that minisatellites most probably evolved as bystanders of localized meiotic recombination hotspots in the human genome.
A minisatellite is a tract of repetitive DNA in which certain DNA motifs ranging in length from 10—60 base pairs are typically repeated times. This article is about the DNA sequence. This article has multiple issues. Please help improve it or discuss these issues on the talk page.
Hypervariable ‘minisatellite’ regions in human DNA.
Such an event would ultimately lead to the extinction of a hypermutable minisatellite by meiotic drive. Oxford University Press is a department of the University of Oxford.
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In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements. This article may be confusing or unclear to readers. Studies have revealed distinct mutation processes operating in somatic and germline cells. Minisatellites consist of repetitive, generally GC -rich, [ citation needed ] motifs that range in length from 10 to over base pairs.
Minisatellites have been associated with chromosome fragile sites and are proximal to a number of recurrent translocation breakpoints.